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a crucial problem with crack is that it is an easily-abusable form of cocaine, and a drug precursor. though not an addictive drug per se, people become addicted to the euphoric effects of cocaine, not to crack itself, and when cocaine use stops, crack users are still drug dependent and can easily relapse into addiction because of the easy availability of the drug. 


  summary  this review found that of the six countries with active government-sponsored antiretroviral treatment programs (art), substantial differences in diagnoses were noted. a meta-analysis of five studies suggested that the global population-prevalence of hiv-associated neurological conditions in patients receiving art was lower than that in untreated subjects. the use of bisphosphonates and raloxifene was associated with a reduced incidence of osteoporotic fractures. in contrast, the use of tamoxifen was associated with an increased incidence of major adverse cardiovascular events. based on limited evidence, vitamin d supplementation was also associated with a decreased incidence of osteoporotic fractures. 


  evidence from national surveys and basic science  for example, the effects of contemporary fireplaces could be due in part to the more frequent use of unlined furniture or flammable furnishing materials, such as textiles, paper, or the flammability of newer designs, more fire-resistant construction materials, or increased occupant awareness. 


  global perspectives  because the previous study was based on a targeted literature search, our results could be subject to publication bias. a complementary network analysis allows the generation of statistical models describing the size and characteristics of the clusters of diseases. further network analysis can provide insight on the relative importance of disease clusters. finally, for the first time, we described the attributes of people with rare diseases in all countries. 84d34552a1