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Gluten-free diet, can result in refractory celiac disease. First proven by Rotterdam in 1999, celiac disease has also been associated with villous atrophy and malabsorption in the absence of serum and intestinal EMA-IgA in the absence of known cause, unlike the celiac patients who maintained normal serum EMA-IgA levels. The mean TTG and EMA-IgA levels in duodenal mucosal biopsies in those with refractory celiac disease are significantly higher than those with no refractory celiac disease (p < 0.05). However, it is important to recognize that the epithelial damage found in patients with refractory celiac disease persists for months to years after the withdrawal of a gluten-free diet. Thus, the use of strict gluten-free diets, in patients with refractory celiac disease, should be accompanied by screening for systemic diseases. Celiac disease has been well-recognized for many decades. However, other gluten-free diets have been applied in recent years, such as the specific diets for the treatment of chronic fatigue syndrome and irritable bowel syndrome.

The news of the 10th edition of Sleisenger and Fordtran's Gastrointestinal and Liver Disease is the timely selection of leading physicians and academicians who cover the latest innovations on a wide range of topics such as advances in the understanding of the pathogenesis and diagnosis of celiac disease, gluten sensitivity, the microbiome, artificial intelligence in diagnosing celiac disease, celiac disease complications, and the emerging role of non-celiac gluten sensitivity. The editors also discuss the new approaches to celiac disease screening, diagnosis, and management of symptoms. The editors have included peer-reviewed original research, reviews of the literature, and clinical cases from their own practices, as well as up-to-date summaries of current guidelines. Kindle edition by Sleisenger; American Gastroenterological Association. Sleisenger GF. Gastroenterology. 10. American Gastroenterological Association. 20th international conference of the American association for gastroenterology. Sleisenger GF; Golovine N; Marchesi L; Belachia G. 20th International conference of the (AAG) Committee on Digestive Diseases. The use of glucagon-like peptide-2 in Crohn's disease. Sleisenger GF; Marchesi L; Belachia G. 20th International conference of the (AAG) Committee on Digestive Diseases. The use of ghrelin agonists in Crohn's disease. Sleisenger GF; Marchesi L; Belachia G. 20th International conference of the (AAG) Committee on Digestive Diseases. Inflammatory bowel disease: non-surgical therapy. Sleisenger GF; Marchesi L; Belachia G. 20th International conference of the (AAG) Committee on Digestive Diseases. Inflammatory bowel disease: the evolving role of surgical therapy. Sleisenger GF; Marchesi L; Belachia G. 20th International conference of the (AAG) Committee on Digestive Diseases. Non-surgical management of inflammatory bowel disease. Sleisenger GF; Marchesi L; Belachia G. 20th International conference of the (AAG) Committee on Digestive Diseases. Sleisenger and Fordtrans Gastrointestinal and Liver Disease (10th Edition). 84d34552a1