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Kessel 205 Book Font Free 12

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in this chapter, we will try to estimate the impact of a hydrogel-forming microneedle patch for painless delivery of the disease modifying drug mtx in in vitro and in vivo studies, and the development of a behavioural based animal model. this drug delivery method could be easily replicated in the clinic for the treatment of kids who suffer from jia.

methods: the work is described in a practical way, and we have provided adequate information on the experimental setup for readers who wish to perform the experiments themselves. the results obtained in the study are analyzed and discussed with the available literature with proper interpretation. it includes: an overview of drug delivery devices, microneedle patches and their application in the treatment of arthritis with special emphasis on the pva-based hydrogel-forming microneedle patch, the behavioural training experiments with the animal model, and the results obtained in the in vitro and in vivo studies 2,3.

in a recent study, we have analysed the effects of long term administration of hydrogel-forming microneedle patch (hm-mn) on the locomotor performance of male and female rats. the patch was placed on the dorsum of rats, and mtx was delivered from the surface of the patch to the skin, and the effects on the performance of rats in various locomotor tasks were analyzed and compared with effects obtained in standard free drug delivery (fd) and blank patch controls. the results obtained in the study shows that children with jia undergoing mtx treatment for 1 year by using microneedle patch with the drug and blank patch without the drug could effectively maintain the performance of these children in various locomotor tasks of their daily life. the finding indicates that this novel therapy is effective in improving the physical activity and specific skills of this group of children, and the findings provide the basis for the development of further studies to demonstrate the safety and efficacy of this novel therapy in various children population. 84d34552a1